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Markedly reduced levels of serotonin in platelets may represent a trait marker for schizophrenia. We measured platelet-associated serotonin uptake in a large series of patients with schizophrenia and unaffected controls. A linear relationship was found between the serum concentration of the serotonin metabolite, 5-hydroxyindoleacetic acid (5-HIAA), and the platelet uptake of 3H-serotonin in patients with schizophrenia (n = 171) and unaffected controls (n = 122). The relationships were similar for patients with paranoid and nonparanoid schizophrenia and controls. There were significant inverse relationships between platelet-associated serotonin uptake and body weight in female patients with nonparanoid schizophrenia and controls, and between platelet-associated serotonin uptake and both age and body weight in male patients with nonparanoid schizophrenia and controls. There were no relationships between body weight and either the serum concentration of serotonin or the platelet-associated serotonin uptake. The findings show the sensitivity of platelet-associated serotonin uptake to relevant environmental factors and provide evidence that the marked reductions of serotonin in platelets of patients with schizophrenia are not simple artifacts of lowered serum serotonin levels.The validity of the parent-report version of the Temperament and Character Inventory (TCI-P).
The Temperament and Character Inventory-Revised (TCI-R) character dimension focuses attention on the more enduring traits of personality. The present study examined the psychometric properties of the parent-report version of the TCI (TCI-P) and examined the relationships of the P scale to the character dimensions. Maternal data for the TCI-P were available from a large sample of mothers (n = 1,074) and their children (n = 1,703), ranging in age from 3 to 20 years. The reliability and validity of the TCI-P were examined in two ways. First, the test-retest reliability of the TCI-P was determined by testing mothers twice during their children’s preschool years. As predicted, there were high test-retest correlations (rs =.91-.97) for the TCI-P dimensions and a corresponding strong test-retest stability coefficient (