The evolution of studies on vaccines against Covid-19 has allowed it to be understood that immunization is indicated for pregnant women, regardless of the gestational period, since the risks are greater for them to develop more dangerous conditions of the disease if they are contaminated. Now, surveys are moving towards understanding the benefits of this public receiving the third dose still pregnant.
A survey conducted by Weill Cornell Medicine and published in the scientific journal “Obstetrics & Gynecology” on December 28 indicates that the consequences are positive for pregnant women who took the booster dose during the third trimester of pregnancy., with significant levels of detectable antibodies both at birth and in the umbilical cord after the baby is born.
The analysis was performed with data from 1,359 pregnant women who had the complete vaccination schedule with Pfizer/BioNTech or Janssen/Johnson & Johnson, plus 20 who received the third dose, and who gave birth at 34 weeks or more. In addition, 1,362 samples of umbilical cord were also collected. Within this group, the first dose was given between December 16, 2020 and September 1, 2021; and the second between January 5 and September 22, 2021. The reinforcement was received between August 27 and October 14, 2021.
“A booster dose in the third trimester was associated with maternal anti-spike IgG levels higher than when vaccination was performed in the third trimester, in women with or without a history of SARS-CoV-2 infection”, indicates the result of the study.
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Although the presence of antibodies was observed in all births, regardless of the gestational age at which the mother was immunized, levels were perceived to be lower when vaccination took place in the first trimester of pregnancy and higher when performed in the third. However, the scenario changes when we talk about the complete vaccine schedule.
“Being fully vaccinated in the first trimester of pregnancy was associated with statistically significantly higher maternal IgG and umbilical cord levels than when the woman received only one dose of vaccine in the third trimester,” the document noted.
As for women who were infected by Covid-19, these indices did not show significant differences when the study compared pregnant women who were fully vaccinated during the nine months and those who had not completed the vaccination schedule while waiting for the birth of their child – which tends to be related with the natural immunity produced after contamination by the virus.
Although the findings are important for the medical community and the population to be increasingly updated on the behavior of the vaccine, the study reinforces that immunization must be performed regardless of gestational age..
Malavika Prabhu, co-author of the study, was emphatic about the encouragement of vaccination during the dissemination of the research. “Women often ask us when is the best time to get vaccinated for their baby – and according to our data, it’s now!” Therefore, when you get pregnant, be sure to talk to your obstetrician so that together you can continue with the vaccination schedule.