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Bipolar disorder (BD) is a severe and chronic disorder characterized by recurrent mood episodes with poor health outcomes, including a high risk of suicide and suicide attempt. Bipolar-related factors, such as high burden of morbidity, adverse physical health conditions and sleep impairment, tend to converge in patients with BD and could act on health-related quality of life (HRQoL). The purpose of this study was to examine the impact of illness-related outcomes (including illness duration and manic and depressive episodes), in addition to inflammation, on HRQoL in BD. The study sample was composed of all consecutive bipolar outpatients admitted to our hospital during a 10-year period. The impact of illness-related factors on HRQoL was assessed using linear regressions. We considered a model with the following predictors: illness duration, manic and depressive episodes, inflammation, and the interaction between these two latter variables. Of the 575 patients who met all inclusion criteria, a total of 221 were eligible for this study; 124 patients completed the complete assessment protocol. A multiple linear regression model showed that, in these patients, longer illness duration was significantly associated with lower HRQoL (β = -0.087, p = 0.010). Having had a manic episode was associated with worse HRQoL (β = -0.356, p Oasis Responds To Nirvana’s Death By Nick Robertson (And Why You Should Care)
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